Aerosol Insulin

Aerosol Insulin. Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulindependent diabetes.

The rationale behind developing a pulmonary drug delivery system is to ensure that insulin powder is delivered deep into the lungs where it is easily absorbed into the bloodstream in a handheld inhalation device The device converts the insulin powder particles into an aerosol cloud for the patient to inhale No propellants are used.

Will Inhaled Insulin Really Take Your Breath Away

It is likely that the treatment of diabetes with aerosolized insulin will provide an effective alternative means for controlling plasma glucose levels in diabetic individuals Aerosolized insulin also will serve as a developmental model for this route of administration for a number of other therapeutic peptides that are currently administered by injection only.

Insulin Human Inhaled (Inhalation Route) Description and

The AERx iDMS produces a fine droplet aerosol (mass median aerodynamic diameter of ∼2–3 μm) from disposable insulin strips by extruding a prepackaged solution through hundreds of laserdrilled holes in a singleuse nozzle ( 10 ) The rapid onset of action of inhaled insulin is very similar to rapidacting insulin analogs ( 11 – 13 ).

Aerosolized liposomes with dipalmitoyl phosphatidylcholine

Concerning needlefree insulins Exubera the first inhaled insulin has been developed by SanofiAventis and Pfizer and marketed by Pzifer in 2006 The idea of administering insulin by breathing an aerosol can be found for the first time in 1925 and has been subsequently relaunched in 1971 (35–37) Investigations carried out by Pfizer Inc.